Evolutionary Plasticity and Innovations in Complex Metabolic Reaction Networks
نویسندگان
چکیده
منابع مشابه
Evolutionary Plasticity and Innovations in Complex Metabolic Reaction Networks
Genome-scale metabolic networks are highly robust to the elimination of enzyme-coding genes. Their structure can evolve rapidly through mutations that eliminate such genes and through horizontal gene transfer that adds new enzyme-coding genes. Using flux balance analysis we study a vast space of metabolic network genotypes and their relationship to metabolic phenotypes, the ability to sustain l...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2009
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1000613